Natural Support for Inflammatory Control
MoveFree Inflamma-Eze™ is a combination of herbs, nutrients and proteolytic enzymes for modulating the inflammatory response, supporting the natural clearance of proteins like kinin and fibrin, and for supporting healthy lymphatic drainage. The ingredients in MoveFree Inflamma-Eze™ provide natural anti-inflammatory effects and protect against oxidative stress.
This powerful formula combines the best of science and enzyme technology for degrading fibrinolytic protein compounds produced during inflammation. The carefully chosen herbs have lipooxygenase (LOX) inhibition, COX 2 inhibition, only mild COX 1 inhibition (to avoid blood thinning and stomach sensitivity), as well as free radical protection. The proteolytic enzymes not only break down inflammatory proteins including kinins and fibrin, but also enhance the breakdown and removal of damaged tissue improving lymphatic drainage.
• Synergistic formula
• Inhibits inflammatory processes in multiple metabolic pathways
• Good safety record and extensive research on all ingredients
• Made with non-GMO ingredients.
• Not recommended for use by pregnant or lactating women.
How to Take:
MoveFree Inflamma-Eze™ is safe to use in high doses yet powerful enough to provide results with as little as two capsules per day. As a dietary supplement, take two capsules per day between meals, or as directed by a health care practitioner. For best results, this product should be taken on an empty stomach, approximately one hour before meals or several hours after.
1 bottle = 60 Vcaps
More technical info:
MoveFree Inflamma-Eze™ ingredients target many metabolic pathways of the inflammatory response1,2
1. Significant inhibition of the COX-2 (cyclooxygenase) enzyme, which produces prostaglandins PG-E2 (inflammatory) and thromboxanes TX-A2 (vasoconstrictive and increases platelet aggregation). The COX-2 inhibition is achieved by turmeric, ginger, quercetin and resveratrol. The PG-E2 is also known to increase cell proliferation, which may be beneficial for normal tissue growth and wound healing but not for cancer promotion. That is why inflammation is associated with the risk of cancer development in many studies and underscores the importance of keeping inflammation under control.
2. Additional inhibition of the expression of the COX-2 enzyme by antioxidant effects on NF-Kappa B, which is one of the regulators of the cytokine (inflammatory) response. This is achieved by the antioxidant action of turmeric, quercetin, rutin, rosemary and resveratrol. This is a preferred mechanism of inhibition because it acts upstream in the metabolic pathway by reducing oxidative stress, which can be one of the causes of inflammation. Thus, this is a preventive action as opposed to blocking inflammation after it has started.
3. MoveFree Inflamma-Eze™ ingredients have a minimal inhibition of the COX-1 enzyme which has a maintenance function for a number of tissues in the body, including intestinal cells. This is unlike aspirin or NSAIDs which are very irritating to the GI tract.
4. MoveFree Inflamma-Eze™ has a mild anti-thrombotic (blood thinning) effect which could result in increased cardiovascular risk protection, similar to that of aspirin yet without aspirin's severe GI irritation. This blood thinning effect of
MoveFree Inflamma-Eze™ is due to the following:
• mild COX-1 inhibition by ginger
• mild anti-coagulating activity of turmeric and quercetin
• fibrinolytic effect of the proteolytic enzymes, especially the serratiopeptidase Cancer metastasis is known to be mediated by increased platelet aggregation, so any agent that decreases it may reduce the risk of cancer proliferation.7
5. MoveFree Inflamma-Eze™ may be superior to selective COX-2 inhibitors like Vioxx and Celebrex due to the fact that, by design, they are lacking any COX-1 inhibiting activity, which affects platelet aggregation. That is why drugs like Vioxx and Celebrex were shown in studies to increase the risk of thrombosis and overall CVD risk. This is especially important for patients with low omega-3 fatty acid stores.
6. MoveFree Inflamma-Eze™ may be superior to selective COX-2 inhibiting drugs due to the fact that in addition to inhibiting COX-2, some MoveFree Inflamma-Eze™ ingredients also inhibit the LOX (lipoxygenase) enzyme. This enzyme is normally producing leukotrienes (LT-4 series) which cause bronchoconstriction and vasoconstriction. The LOX inhibition is achieved through the action of boswellia, turmeric, ginger and quercetin.
7. MoveFree Inflamma-Eze™ may be superior to the typical anti-asthma drugs that are only leukotriene receptor blockers. This is because MoveFree Inflamma-Eze™ reduces the formation of leukotrienes (LT) in the first place as opposed to just blocking certain LT receptors, as the drugs do.
8. One additional advantage that MoveFree Inflamma-Eze™ has over selective anti-inflammatory drugs is that it combines many benefits in one, blocking various pathways at the same time. When any one drug is given, it only blocks one arachidonic acid (AA) pathway. For example, Vioxx and Celebrex block only COX-2, which causes an overflow of AA into the other pathway, the LOX-1. That is why COX-2 inhibiting drugs are known to have side effects such as increased incidence of asthma.
9. Some of MoveFree Inflamma-Eze's ingredients were shown to block phospholipase A2 (turmeric, ginger) or TNF-alpha (quercetin), which is similar to what corticosteroids do, but without their side effects.
References 1. FitzGerald GA, Patrono C. The coxibs, selective inhibitors of cyclooxygenase-2. N Engl J Med. 2001 Aug 9;345(6):433-42. 2. De Caterina R, Zampolli A. From asthma to atherosclerosis--5-lipoxygenase, leukotrienes, and inflammation. N Engl J Med. 2004 Jan 1;350(1):4-7. 3. Ammon HP, Safayhi H. Mechanism of antiinflammatory actions of curcumine and boswellic acids. J Ethnopharmacol. 1993 Mar; 38(2-3):113-9. 4. Kiuchi F, Iwakami S. Inhibition of prostaglandin and leukotriene biosynthesis by gingerols and diarylheptanoids. Chem Pharm Bull (Tokyo). 1992 Feb; 40(2): 387-91. 5. Guardia T, Rotelli AE. Anti-inflammatory properties of plant flavonoids. Effects of rutin, quercetin and hesperidinon adjuvant arthritis in rat. Farmaco. 2001 Sep;56(9):683-7. 6. Lo AH, Liang YC. Carnosol, an antioxidant in rosemary, suppresses inducible nitric oxide synthase through down-regulating nuclear factor-kappaB in mouse macrophages. Carcinogenesis. 2002 Jun;23(6):983-91. 7. Surh YJ. Anti-tumor promoting potential of selected spice ingredients with antioxidative and anti-inflammatory activities: a short review. Food Chem Toxicol 2002 Aug;40(8):1091-7. 8. Satoskar RR, Shah SJ. Evaluation of anti-inflammatory property of curcumin (diferuloyl methane) in patients with postoperative inflammation. Int J Clin Pharmacol Ther Toxicol. 1986 Dec; 24(12): 651-4